Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients

Obesity is a significant global public health concern that associated with an elevated risk of comorbidities as well severe postoperative and nosocomial infections. The treatment infections in critically ill obese patients can be challenging because obesity affects the pharmacokinetics pharmacodynamics antibiotics, leading to increased antibiotic therapy failure toxicity due inappropriate dosages. Precision dosing antibiotics using therapeutic drug monitoring may help improve management this patient population. This narrative review outlines pharmacokinetic pharmacodynamic changes result from provides comprehensive critical current available data on dosage adjustment patients.